Kudzu Extract Treatment Does Not Increase the Intoxicating Effects of Acute Alcohol in Human Volunteers PMC

Dihydromyricetin (DHM), a flavonoid separated from Hovenia dulcis, was identified to interact with γ-aminobutyric acid receptors and block alcohol intoxication and withdrawal signs in rats such as tolerance, increased anxiety, and seizure susceptibility. DHM could remarkably reduce alcohol digestion in a voluntary alcohol intake paradigm in rats. At the cellular level, DHM treatment antagonized potentiation of GABAA receptors and plasticity. Therefore, DHM could be used as a therapeutic candidate for alcohol use disorders [44,65].

  • In humans, benefits from kudzu on hot flashes, night sweats, and cognitive function are also attributed to isoflavones (5) (6).
  • Three questions asked them to report how many alcoholic drinks, tobacco cigarettes and caffeinated beverages they consumed and two questions asked about bedtime and wake time.
  • The reduction in alcohol intake was compensated by an increase in water intake [112].
  • Participants were instructed to always keep the beer glass on the table except when taking a sip.
  • It is quite likely that the desire to use alcohol in an outpatient setting cannot be captured with a single question; we also observed an absence of an effect on desire for alcohol in our previous study (Lukas et al., 2005).

The study showed that FPEt ameliorated the pathological liver changes and changed protein expression in Chang liver cells as well as improved the levels of antioxidant enzymes. The effects of FPEt were identical to those of the known hepatoprotective agent, silymarin. FPEt might exert cytoprotective effects by enhancing cellular redox status [53]. Treatment with FPEt restored the levels of markers of liver injury (AST, ALT, ALP, lactate dehydrogenase (LDH), bilirubin and GGT) and enhanced alcohol metabolizing and detoxification enzymes, as well as the electron transport component cytochrome-c reductase.

Treatment with kudzu extract does not cause an increase in alcohol’s intoxicating effects, study finds

Role of Funding Source Funding for this study was provided by NIAAA grant R01-AA10536 to Dr. Lukas and NCCAM grant P01-AT to Dr. Lee. The NIAAA and NCCAM had no further role in the study design; in the collection, analysis and interpretation https://ecosoberhouse.com/ of data; in the writing of the report; or in the decision to submit the paper for publication. The room contained a small sink with an under-the-counter refrigerator where the beverages (beer, juice, and water) were kept.

This double-blind, placebo-controlled, crossover trial tested the effects of kudzu root extract on the sleep/wake cycles of moderate drinkers. Kudzu extracts contain several compounds, with the highest concentration being isoflavones. The three major ones, puerarin, daidzin and daidzein have been the focus of attention for their likely contributions to the effects of the raw roots on drinking. While some investigators have focused on daidzin because of its weak antabuse-like effect (Arolfo et al, 2009), we believe that puerarin is responsible for bioactivities of kudzu. While it is less potent than the others, there is far more of it in the plant, and it turns out that puerarin has a unique pharmacology.

Plasma Ethanol Levels

All of the above mentioned mechanisms, with the exception of a disulfiram-like one, require repeated administration and time to develop. Since consuming alcohol while taking kudzu extract is not aversive, another explanation is necessary to account for the extremely fast onset https://ecosoberhouse.com/article/kudzu-extract-and-alcohol-addiction-can-it-help-you-drink-less/ of action observed in the present study. The correlational analysis of absolute amount of alcohol consumed and breath alcohol levels in this study indicates that the physiological effects and the rate of elimination of ingested alcohol are not altered by kudzu administration.

kudzu extract for alcoholism

The two treatments (kudzu and placebo) were analyzed as fixed effects and time (weeks since randomization) as a repeated-measurements effect. In all analyses, the baseline drinking level was modeled as a covariate of the respective dependent variable (e.g., the number of drinks per day in the baseline phase was modeled as a covariate when the dependent variable was the number of drinks during the treatment phase). Effect size is reported using the variance-accounted for statistic Partial Eta-Squared (η2Partial). All tests were two-sided with significance level of 0.05 and were performed using SPSS software (version 19.0, IBM SPSS, Inc, Chicago, IL).

For Patients & Caregivers

It is important to place the magnitude of the effects of kudzu extract on alcohol drinking in context. Alcohol drinking was not completely eliminated by kudzu extract in the present study, but was reduced from baseline drinking by an average of 45% over the four weeks of treatment. From a harm reduction perspective, kudzu extract results in a desirable outcome for a population of heavy drinkers, especially when one considers the other important finding of the present study—kudzu extract was without any adverse events and minimal side effects. We recently demonstrated that kudzu extract does not potentiate the intoxicating effects of alcohol (Penetar et al., 2010) and it does not interfere with sleep wake activity (Bracken et al., 2011). In addition, this was not a treatment clinical trial, so the effects on alcohol intake might have been more robust in treatment-seeking individuals.

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